DNA-PAINT method available at OICE

Symbolic picture for the article. The link opens the image in a large view.
2-Colour DNA-PAINT Tubulin and Vimentin

OICE now has another option in its range of methods for achieving single-molecule resolution, particularly in membranes.
This is points accumulation for imaging nanoscale topography (PAINT). This will be systems that use DNA to achieve repeated, transient binding for PAINT. Thus, single molecule localisation microscopy (SMLM) has become affordable for imaging single molecules without the need to purchase a super-resolution microscope for well over 1 million euros. A good TIRF system in combination with DNA-PAINT now enables the resolution and quantification of single biomolecules. OICE has antibodies available to image up to three channels with DNA-PAINT. The picture shows a double staining, once against vimentin and against tubulin.

Two good reads:

Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation

DNA-Based Super-Resolution Microscopy: DNA-PAINT