Exploratory Research Unit (ERU)
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Uderhardt Group
We will use integrative tissue-level bio-imaging to elucidate the cellular and molecular mechanisms tissues employ to protect themselves against unwanted immune responses. Specifically, We will focus on the biology and the homeostatic functions of interstitial macrophages in vivo and explore how these cells operate during the onset of inflammation. Ultimate goal of my research is to therapeutically exploit the tissue-protective properties of these cells in order not only to treat but also prevent inflammatory diseases. As part of the OICE-ERU we will establish and further advance intravital as well as in situ functional imaging approaches as tools for the Exploration of spatiotemporal dynamics of immune effector cells within the context of biological tissues.
| Orcid | Google Scholar |
Selected Publications:
- Freeman et al., Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance. Science 2020.
- Uderhardt et al., Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 2019.
- Uderhardt et al., Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. J Exp Med 2017.
- Uderhardt et al., 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity 2012.
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Dulin Group
